Journal article
A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1
M Lemire, C Qu, LWM Loo, SHE Zaidi, H Wang, SI Berndt, S Bézieau, H Brenner, PT Campbell, AT Chan, J Chang-Claude, M Du, CK Edlund, S Gallinger, RW Haile, TA Harrison, M Hoffmeister, JL Hopper, L Hou, L Hsu Show all
Human Genetics | SPRINGER | Published : 2015
Abstract
Over 50 loci associated with colorectal cancer (CRC) have been uncovered by genome-wide association studies (GWAS). Identifying additional loci has the potential to help elucidate aspects of the underlying biological processes leading to better understanding of the pathogenesis of the disease. We re-evaluated a GWAS by excluding controls that have family history of CRC or personal history of colorectal polyps, as we hypothesized that their inclusion reduces power to detect associations. This is supported empirically and through simulations. Two-phase GWAS analysis was performed in a total of 16,517 cases and 14,487 controls. We identified rs17094983, a SNP associated with risk of CRC [p = 2...
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Grants
Awarded by Groupement des Entreprises Françaises dans la lutte contre le Cancer
Funding Acknowledgements
CANCER PREVENTION STUDY II: CPS-II is supported by the American Cancer Society (ACS). We would like to thank the CPS-II participants and the CPS-II Study Management Group for their invaluable contributions to this research. The authors would also like to acknowledge the contribution to this study from central cancer registries supported through the Centers for Disease Control and Prevention National Program of Cancer Registries, and cancer registries supported by the National Cancer Institute Surveillance Epidemiology and End Results program.